It is clear that there are definite changes in the way the brain works when a person is depressed:
- Modern brain scans that can look at how 'hard' the brain is working have shown that some areas of the brain (such as at the front) are not working as well as normal.
- Depressed patients have higher than normal levels of stress hormones.
- Various chemical systems in the brain may not be working correctly including one known as the serotonin or 5-HT system.
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